Hotels in South Carolina Lowcountry

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Where to stay in South Carolina Lowcountry?

Red Roof Inn Yemassee
Lobby

Red Roof Inn Yemassee

2.0 star property
7.4 out of 10, Good, (541)
The price is $81
includes taxes & fees
$74 per night
Apr 24 - Apr 25
Red Roof Inn Yemassee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in South Carolina Lowcountry, SC

Showing deals for:May 2 - May 4

Image gallery for The Westin Hilton Head Island Resort & Spa

2 bars/lounges, poolside bar

The Westin Hilton Head Island Resort & Spa

4.0 star property
Hilton Head Island
8.4/10Very Good (1,005 reviews)
15% off
Price is $411
per night
$998 total
includes taxes & fees
The Westin Hilton Head Island Resort & Spa

Top neighborhoods in South Carolina Lowcountry

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Sea Pines

Hilton Head Island's Sea Pines neighborhood has a host of places to visit such as Atlantic Dunes by Davis Love III and Harbour Town Golf Links.

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Sea Pines

Top landmarks in South Carolina Lowcountry

Marine Corps Recruit Depot Parris Island

Marine Corps Recruit Depot Parris Island

Marine Corps Recruit Depot Parris Island is worth a visit, located 0.6 mi (0.9 km) from central Parris Island. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches.

See properties in Marine Corps Recruit Depot Parris Island
Marine Corps Recruit Depot Parris Island

Learn more about South Carolina Lowcountry

South Carolina Lowcountry is applauded for its cultural attractions such as Parris Island Museum and Highway 21 Drive-In Theater.

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Hilton Head featuring heritage architecture
Photo by Hilton Head Island Visitor & Convention Bureau
Open Photo by Hilton Head Island Visitor & Convention Bureau
A tranquil hotel pool encircled by beautiful arches, enhancing the ambiance for leisure and relaxation.

Summer Getaway Sale

Save 25% or more on select hotels, and earn 50% more rewards on all properties. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

What hotels do travelers recommend in South Carolina Lowcountry?
The Inn & Club at Harbour Town, Montage Palmetto Bluff and Hilton Grand Vacations Club Ocean Oak Resort Hilton Head are all properties that our guests really like.
Can I book refundable hotels in South Carolina Lowcountry?
If you want the flexibility to change your travel plans to South Carolina Lowcountry, most hotels provide refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow down the results.
Which South Carolina Lowcountry hotels do our guests like for their terrific location?
Our guests love these properties for their convenient location: Beach House Resort Hilton Head, Microtel Inn & Suites by Wyndham Walterboro and Quality Inn At Town Center.
Where should I consider staying in South Carolina Lowcountry if I'm looking for a budget-friendly accommodation?
Best Western Plus Hardeeville Inn & Suites, Microtel Inn & Suites by Wyndham Walterboro and Red Roof Inn Hardeeville are a few accommodations you might want to consider that’ll save you money. You may want to browse more choices on our site, including 17 motels.
Where can I stay in South Carolina Lowcountry if I want a vacation home instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 4188 vacation homes. In addition, there are 225 apartments and 3043 condos.
Why should I book my South Carolina Lowcountry accommodation with Hotels.com?
There are lots of reasons to book your South Carolina Lowcountry trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com® app users and One Key members. Limited availability, blackout periods may apply.

OneKeyCash is not redeemable for cash and can only be used on Hotels.com®, Expedia®, and Vrbo®.

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